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Nutrition and cancer: essential elements for a roadmap
1Nutritional Sciences Research Group, Division Cancer Prevention, NCI/NIH/HHS, 6130 Executive Boulevard, Executive Plaza North, Suite 3164, Rockville, MD 20852, USA. milnerj@mail.nih.gov
Abstract:
Personalizing nutrition for cancer prevention and therapy will require a comprehensive understanding of "genotypes/phenotypes" in order to identify, evaluate, and prioritize appropriate points for dietary intervention. This nutritional preemption roadmap must begin with accurately assessing intakes/exposures of which bioactive food component(s) is needed to bring about a desired response in critical cellular processes (carcinogen metabolism, DNA repair, cell proliferation, apoptosis, inflammation, immunity, differentiation, angiogenesis, hormonal regulation and cellular energetic) within an individual. Understanding this "individuality" through a better understanding of the "omics" is fundamental to arriving at the correct destination and thus interpreting biological variables which establish the magnitude or direction of a response to bioactive food components.
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