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A case of CD45-negative diffuse large B-cell lymphoma in thyroid gland
Tohru Inaba1, Hiroshi Nishimura, Junko Saito
1Department of Infection Control and Laboratory Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan. inaba178@koto.kpu-m.ac.jp
Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
|July 5, 2008
Summary
This study reports a rare case of CD45-negative non-Hodgkin's lymphoma (NHL) in the thyroid. CD45 is typically found on blood cells and most hematologic cancers, making this case unusual.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- CD45, or leukocyte common antigen (LCA), is a protein tyrosine phosphatase widely expressed on hematopoietic cells.
- Its expression is a common marker in hematologic malignancies, aiding in diagnosis and classification.
- However, variable CD45 expression is observed in certain leukemias and multiple myeloma.
Observation:
- A rare case of non-Hodgkin's lymphoma (NHL) affecting the thyroid gland was identified.
- This specific NHL case exhibited a distinct lack of CD45 expression.
- The patient presented with a thyroid mass confirmed as CD45-negative NHL.
Findings:
- The study documents an unusual instance of CD45-negative non-Hodgkin's lymphoma.
- This finding challenges the typical expression patterns of CD45 in hematologic malignancies.
- The thyroid gland was the primary site of this rare CD45-negative NHL.
Implications:
- This case highlights the importance of considering CD45-negative variants in diagnosing hematologic malignancies, even in extranodal sites like the thyroid.
- Further research may be needed to understand the biology and clinical behavior of CD45-negative NHL.
- Diagnostic protocols for lymphoma should account for potential CD45-negative cases, especially in thyroid presentations.
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