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Related Experiment Video

Updated: Jul 3, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Risk of thrombogenicity among nonionic radiocontrast agents.

Alexander Georgakis¹, Rasih Atilla Ener, Jianguo Jin

¹Division of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

The Journal of Invasive Cardiology

|July 5, 2008

Summary

Newer nonionic contrast agents show minor differences in thrombogenicity. At higher concentrations (50%), they inhibit platelet aggregation, potentially by affecting calcium mobilization.

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Area of Science:

Radiology
Pharmacology
Biomedical Engineering

Background:

Older ionic, high-osmolar contrast agents are largely replaced by nonionic, low or iso-osmolar agents due to better safety and tolerability.
Nonionic contrast media are widely used in radiographic imaging.

Purpose of the Study:

To investigate the thrombogenicity of six different nonionic radiocontrast media.
To compare their effects on platelet reactivity.

Main Methods:

Evaluation of platelet reactivity and aggregation.
Testing of six nonionic radiocontrast media at 50% and 10% concentrations.
Comparison with a normal control group.

Main Results:

Minor differences in thrombogenicity were observed among the nonionic contrast agents.
At 50% concentration, all agents inhibited platelet aggregation.
At 10% concentration, all agents showed aggregation curves similar to the control.
The inhibitory effect at 50% concentration correlated with inhibited calcium mobilization.

Conclusions:

Nonionic contrast agents exhibit varying degrees of thrombogenicity.
Inhibition of platelet aggregation at higher concentrations may involve calcium mobilization pathways.
Further research into the mechanistic effects of contrast agents on platelet function is warranted.