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Updated: Jul 3, 2026

A Flow Adhesion Assay to Study Leucocyte Recruitment to Human Hepatic Sinusoidal Endothelium Under Conditions of Shear Stress
Published on: March 21, 2014
Leucocyte adhesion defect-1
K Jothilakshmi1, Sugantha Priya, John Matthai
1Department of Pediatrics, PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore, Tamil Nadu, India. psg_peds@yahoo.com
Abstract:
Leucocyte adhesion defect (LAD) is an inherited disorder of phagocytic function. It is characterized by inability of the leucocytes, in particular neutrophilis to migrate from the blood stream towards sites of inflammation. LAD -1 is characterized by the absence of b 2 integrins (CD 11 / CD18) on leucocytes. This disorder is characterized by delayed separation of the umbilical cord, recurrent severe infections, periodontitis, and delayed wound healing. We report an infant where the diagnosis was confirmed by flow cytometry.
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