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Diabetes mellitus: is it protective against aortic root dilatation?
Xiao-Feng Chen1, Jian-An Wang, Xian-Fang Lin
1Division of Cardiology, No. 2 Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, PR China.
Cardiology
|July 5, 2008
Summary
Type 2 diabetes is linked to smaller aortic root dimensions. This study found significantly reduced aortic root size in diabetic patients compared to non-diabetic individuals, suggesting a protective effect against aortic root dilation.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Medical Imaging
Background:
- Diabetes mellitus is associated with abdominal aortic aneurysms and increased aortic diameter.
- Limited data exists on the relationship between diabetes and aortic root diameter.
Purpose of the Study:
- To investigate the association between type 2 diabetes and aortic root dimensions.
- To compare the prevalence of aortic regurgitation in diabetic versus non-diabetic individuals.
Main Methods:
- Two-dimensional echocardiography was used to measure aortic root dimensions in 109 patients with type 2 diabetes and 218 controls.
- Measurements included the aortic annulus, sinus of Valsalva, sinotubular junction, and proximal ascending aorta.
- Prevalence of aortic regurgitation was compared between groups.
Main Results:
- Patients with type 2 diabetes exhibited significantly smaller mean aortic root dimensions compared to non-diabetic controls (p < 0.05).
- Aortic root dilatation was less prevalent in diabetic patients (2.75%) than in non-diabetic subjects (9.63%; p = 0.025).
- Diabetes was a significant negative determinant of aortic root size across all measured sites.
Conclusions:
- Type 2 diabetes is associated with significantly smaller aortic root dimensions.
- Diabetic patients demonstrated a lower prevalence of aortic root dilatation.
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