Life-threatening bite injury of the lower lip after use of metamizole
Related Experiment Video
Updated: Jul 3, 2026

A Lip Fixation Device Facilitates Labial Salivary Gland Biopsy for Sjögren's Disease
Published on: March 6, 2026
S T Becker1, J Wiltfang, I N Springer
1Department of Oral and Maxillofacial Surgery, University of Kiel, 24105 Kiel, Germany. becker@mkg.uni-kiel.de
Introduction:
Bite wounds of the oral mucosa heal after eliminating the causative irritant, but there are serious exceptions from the rule. We present the case of a 37-year-old woman with an ulcer of the mucosa of the lower lip, which had been present for 10 days, and leucopenia.
Discussion:
Agranulocytosis after the use of metamizole is part from leukaemia and lues, a rare reason for non-healing ulcers of the mucosa of the oral cavity without fulminant signs for inflammation.
Conclusion:
As this is a life-threatening disease, medical therapy must begin immediately.
Related Concept Videos
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Rocky Mountain Spotted Fever
Drug Delivery: Enteral Route
Drugs in...
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Parenteral Anesthetics: Overview