Related Experiment Video

Updated: Jul 3, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

The prevalence of celiac disease in blood donors in Iceland

Gudmundur F Johannsson1, Gudjon Kristjansson, Nick Cariglia

  • 1Department of Medicine, FSA University Hospital, 600, Akureyri, Iceland.

Digestive Diseases and Sciences
|July 5, 2008
PubMed

Insights

The prevalence of celiac disease in Iceland was found to be 0.74% among blood donors. This finding indicates that celiac disease is as common in Iceland as in other countries.

Area of Science:

  • Epidemiology
  • Gastroenterology
  • Immunology

Background:

  • Celiac disease is more prevalent than previously recognized, according to serological studies.
  • Understanding the prevalence of celiac disease in diverse populations is crucial.

Purpose of the Study:

  • To determine the prevalence of celiac disease in apparently healthy Icelandic blood donors.
  • To contribute to the epidemiological understanding of celiac disease.

Main Methods:

  • Screening of 813 blood donor plasma samples for human tissue transglutaminase IgA antibodies.
  • Positive serological results were confirmed through clinical examination, duodenoscopy, and mucosal biopsies.

Main Results:

  • Six subjects tested positive for tissue transglutaminase antibodies.
  • Biopsy-confirmed celiac disease prevalence was determined to be 1:136 (0.74%) among blood donors.
  • The 95% confidence interval for prevalence was 0.15-1.33%.

Conclusions:

  • The prevalence of celiac disease in Iceland is comparable to that reported globally.
  • This study highlights the importance of screening in blood donor populations.
Abstract

More Related Videos

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

Environmental DNA Sampling from Whale-Watching Vessels for Cetacean Monitoring08:07

Environmental DNA Sampling from Whale-Watching Vessels for Cetacean Monitoring

Published on: April 10, 2026

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...