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Updated: Jul 3, 2026

Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury
Published on: May 7, 2015
Metabolism and distribution of guanosine given intraperitoneally: implications for spinal cord injury
Shucui Jiang1, Gemma Fischione, Patricia Giuliani
1Department of Surgery, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada. jiangs@mcmaster.ca
Abstract:
Intraperitoneal administration of guanosine to rats with chronic spinal cord injury stimulates remyelination and functional recovery. If guanosine produced its effects in the nervous system, it should enter it and elevate endogenous concentrations. [(3)H]-guanosine (8 mg/kg) was administered intraperitoneally to rats and its distribution and concentration in different sites determined. Guanosine rapidly entered all tissues; its concentration peaked at about 15 minutes except in adipose tissue and CNS where it continued to rise for 30 minutes. Its chief metabolic product in all sites was guanine with over twice as much guanine as guanosine present in CNS after 30 minutes.
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