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Updated: Jul 3, 2026

Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow
Published on: August 14, 2014
Regulation of leukocyte migration across endothelial barriers by ECTO-5'-nucleotidase-generated adenosine
Linda F Thompson1, Masahide Takedachi, Yukihiko Ebisuno
1Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA. Linda-Thompson@omrf.org
Abstract:
CD73-deficient mice are valuable for evaluating the ability of CD73-generated adenosine to modulate adenosine receptor-mediated responses. Here we report the role of CD73 in regulating lymphocyte migration across two distinct barriers. In the first case, CD73-generated adenosine restricts the migration of lymphocytes across high endothelial venules (HEV) into draining lymph nodes after an inflammatory stimulus, apparently by triggering A(2B) receptors on HEV. Secondly, CD73 promotes the migration of pathogenic T cells into the central nervous system during experimental autoimmune encephalomyelitis. Experiments are in progress to determine whether this effect is also adenosine receptor-mediated and to identify the relevant adenosine receptor.
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