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Related Concept Videos

Bioreactor Controls-I01:28

Bioreactor Controls-I

Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...
Bioreactor Controls-III01:22

Bioreactor Controls-III

Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
Microbes in Food Production01:29

Microbes in Food Production

Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
Bioreactor Controls-II01:18

Bioreactor Controls-II

In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the fermentor via a sparger...
Scale-Up Processes01:14

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
Production of Alcohol01:27

Production of Alcohol

Continuous fermentation is a key strategy in industrial ethanol production, particularly when efficiency, scalability, and high yields are essential. This approach allows for uninterrupted operation and optimized resource utilization. The primary feedstock, corn starch, undergoes enzymatic hydrolysis facilitated by α-amylase and glucoamylase. These enzymes break down the starch into fermentable sugars such as glucose, which are readily assimilated by fermentative microorganisms.Fermentation...

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Light-Controlled Fermentations for Microbial Chemical and Protein Production
08:37

Light-Controlled Fermentations for Microbial Chemical and Protein Production

Published on: March 22, 2022

Knowledge-based control of fermentation processes.

K B Konstantinov1, T Yoshida

  • 1International Center of Cooperative Research in Biotechnology, Faculty of Engineering, Osaka University, Yamada-oka, Suita-shi, Osaka, Japan.

Biotechnology and Bioengineering
|March 5, 1992
PubMed
Summary
This summary is machine-generated.

Intelligent control, using knowledge-based systems, has significantly advanced bioprocess control over the past decade. These sophisticated methods are now mature and poised for widespread adoption in biotechnology and fermentation processes.

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Area of Science:

  • Biotechnology
  • Process Control
  • Artificial Intelligence

Background:

  • The last decade has seen significant evolution in intelligent control for bioprocesses.
  • Real-time expert systems have driven progress in knowledge-based control methodologies.
  • Biotechnology increasingly utilizes advanced control strategies.

Purpose of the Study:

  • To summarize achievements in knowledge-based bioprocess control.
  • To discuss current trends and challenges in the field.
  • To highlight the inevitable large-scale application of these systems.

Main Methods:

  • Review of knowledge-based approaches in bioprocess control.
  • Analysis of the evolution of intelligent control concepts and tools.
  • Synthesis of research trends from academic and industrial sectors.

Main Results:

  • Knowledge-based control methodologies for fermentation processes have matured.
  • Significant progress has been made in concepts, objectives, and tools for intelligent control.
  • Research indicates a strong trend towards large-scale implementation.

Conclusions:

  • Knowledge-based systems represent a mature and evolving area within bioprocess control.
  • The field is characterized by growing interest and intensive research.
  • Widespread application of intelligent control in biotechnology is anticipated.