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A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

Published on: February 10, 2023

Mixing in liquid-impelled loop reactors.

H M Van Sonsbeek¹, S P Van Der Tuin, J Tramper

¹Food and Bioprocess Engineering Group, Department of Food Science, Agricultural University Wageningen, EV Wageningen, The Netherlands.

Biotechnology and Bioengineering

|March 25, 1992

Summary

This summary is machine-generated.

A novel liquid-impelled loop reactor uses descending perfluorochemical drops for aqueous phase circulation. This bioreactor design offers efficient mixing and aids in calculating circulation times for optimized performance.

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A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities

Published on: December 25, 2015

Area of Science:

Biochemical Engineering
Chemical Reaction Engineering
Fluid Dynamics

Background:

The air-lift loop reactor is a common bioreactor design.
Efficient mixing is crucial for bioreactor performance.
Novel reactor designs are needed to improve mass transfer and mixing.

Purpose of the Study:

To introduce and characterize a new column-type bioreactor: the liquid-impelled loop reactor.
To analyze the mixing characteristics and hydrodynamics of this novel reactor.
To compare its performance with existing bioreactor systems like bubble columns and air-lift loop reactors.

Main Methods:

Utilized an external-loop configuration with descending perfluorochemical drops to drive aqueous phase circulation.
Measured and analyzed mixing characteristics in different sections of the reactor.
Determined axial-dispersion coefficients for the two-phase flow and correlated them with energy dissipation.
Compared hydrodynamic models and derived overall mixing parameters.

Main Results:

Descending perfluorochemical drops effectively circulated the continuous aqueous phase.
Axial-dispersion coefficients were determined and correlated with energy dissipation.
Overall mixing parameters were derived, enabling calculation of necessary circulations for desired mixing levels.
The hydrodynamic model was validated for the tested reactor configurations.

Conclusions:

The liquid-impelled loop reactor demonstrates effective mixing driven by liquid-liquid two-phase flow.
The derived parameters and validated hydrodynamic model facilitate the prediction of circulation times and optimization of bioreactor performance.
This novel bioreactor design shows promise as an alternative to conventional systems for specific applications.