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Determination of the interparticular effective diffusion coefficient for CO(2) and O(2) in solid state fermentation.

R Auria¹, J Palacios, S Revah

¹Departmento de Ingeniería de Procesos e Hidraulica, Universidad Autónoma Metropolitana-Iztapalapa, México D.F., Mexico.

Biotechnology and Bioengineering

|April 15, 1992

Summary

A novel diffusion controlled fermentor (DCF) and mathematical model were developed to measure gas diffusion coefficients in solid-state fermentation. Biomass concentration significantly impacts gas diffusion, reducing it to 5% of air values at high biomass levels.

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Area of Science:

Biochemical Engineering
Bioprocess Engineering
Biotechnology

Background:

Solid-state fermentation (SSF) is a key bioprocess, but understanding gas diffusion limitations is crucial for optimization.
Accurate measurement of gas diffusion coefficients (CO2 and O2) is essential for modeling and controlling SSF processes.

Purpose of the Study:

To propose a simple experimental diffusion controlled fermentor (DCF) for measuring gas diffusion coefficients in SSF.
To develop a mathematical model based on mass balance to quantify gas diffusion variations.

Main Methods:

Utilized a DCF packed with ion-exchange resin and inoculated with Aspergillus niger.
Simulated convective oxygen supply conditions to mimic industrial equipment.
Employed a mass balance model to analyze gas (CO2 and O2) diffusion.

Main Results:

Demonstrated that gas diffusion coefficients are highly dependent on biomass concentration in SSF.
Observed a significant reduction in diffusion coefficients, reaching <5% of air values at 27 mg dry/g dry support biomass concentration.

Conclusions:

The developed DCF and model provide a reliable method for assessing gas diffusion in SSF.
Biomass accumulation is a critical factor limiting gas transport, impacting process efficiency and scale-up.