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Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations

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Oxygen transfer in liquid-impelled loop reactors using perfluorocarbon liquids.

H M van Sonsbeek¹, H De Blank, J Tramper

¹Food and Bioprocess Engineering Group, Department of Food Science, Agricultrual University Wageningen, Wageningen, The Netherlands.

Biotechnology and Bioengineering

|September 1, 1992

Summary

This summary is machine-generated.

Oxygen transfer in liquid-impelled loop reactors using perfluorochemical FC40 shows a lower mass-transfer coefficient (k) but favorable specific exchange area. Slow drop coalescence limits flow rates, requiring solutions for efficient oxygen supply.

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Area of Science:

Chemical Engineering
Bioreactor Design
Mass Transfer

Background:

Liquid-impelled loop reactors offer unique configurations for gas-liquid mass transfer.
Perfluorochemicals like FC40 are utilized for specific applications requiring enhanced oxygen solubility.
Understanding oxygen transfer dynamics is critical for optimizing bioreactor performance.

Purpose of the Study:

To investigate oxygen transfer characteristics in a liquid-impelled loop reactor externally aerated with perfluorochemical FC40.
To compare the mass-transfer coefficient and specific exchange area with conventional gas-liquid systems.
To identify limitations and propose solutions for optimizing oxygen supply in this reactor setup.

Main Methods:

Experimental investigation of oxygen transfer in two sizes of liquid-impelled loop reactors.
Aeration of perfluorochemical FC40 with external air supply.
Measurement and analysis of mass-transfer coefficient (k) and specific exchange area.

Main Results:

The mass-transfer coefficient (k) was found to be approximately 0.6 times lower compared to typical gas-liquid systems.
The specific exchange area in the experimental setup was favorable relative to gas-liquid bioreactors at similar superficial dispersed-phase velocities.
Slow coalescence of dispersed FC40 drops in the phase separation section significantly limited the dispersed-phase flow rate.

Conclusions:

While the specific exchange area is advantageous, the overall oxygen transfer efficiency is impacted by a reduced mass-transfer coefficient.
The slow coalescence of the dispersed phase is a critical bottleneck for achieving higher dispersed-phase flow rates and thus oxygen supply.
Further research or alternative strategies, such as combined air and solvent sparging, are necessary to overcome limitations and enhance oxygen transfer in this system.