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Rheological characterization of media containing Penicillium chrysogenum

A G Pedersen1, M Bundgaard-Nielsen, J Nielsen

  • 1Department of Biotechnology, The Technical University of Denmark, Center for Process Biotechnology, DK-2800 Lyngby, Denmark.

Biotechnology and Bioengineering
|January 5, 1993
PubMed

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Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...