Mid-infrared reflectivity of experimental atheromas
Hoi-Ying N Holman1, Kathy A Bjornstad, Michael C Martin
1University of California, Berkeley, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. hyholman@lbl.gov
Abstract:
We report that the pathologic components present within the atheromatous plaques of ApoE knock-out mice can reflect significant amounts of mid-infrared (mid-IR) light. Furthermore, the reflected light spectra contained the unique signatures of a variety of biologic features including those found in unstable or "vulnerable" plaque. This discovery may represent a unique opportunity to develop a new intravascular diagnostic modality that can detect and characterize sites of atherosclerosis.
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