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Histopathological findings in extended prostate biopsy with PSA < or = 4 ng/mL
Katia R Leite1, Miguel Srougi, Marcos F Dall'Oglio
1Laboratory of Medical Investigation-LIM55 University of Sao Paulo, USP, SP, Brazil. katiaramos@uol.com.br
Objective:
Cancer detection has been reported in up to 27% of patients when lowering the PSA cutoff to 2.5 ng/mL. Although this practice could increase the number of biopsies performed, it also could lead to more frequent detection of significant prostate cancers at an organ-confined stage and/or a less aggressive state. This study describes the incidence of malignancy and tumor characteristics in extended prostate biopsies with PSA
Materials And Methods:
Prostate biopsies from 1081 patients where examined, 275 (25.4%) patients had PSA level
Results:
Cancer was diagnosed in 32.0% and 35.7% of patients with PSA
Conclusion:
When PSA is below 4 ng/mL, cancer is detected in a proportion equal to the proportion diagnosed with a PSA >4 ng/mL, and tumor characteristics are similar between the two groups. Only clinically significant tumors were diagnosed following radical prostatectomy.
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