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Simultaneous determination of artemether and lumefantrine in fixed dose combination tablets by HPLC with UV detection

Isabela da Costa César1, Fernando Henrique Andrade Nogueira, Gérson Antônio Pianetti

  • 1Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil. isaccesar@bol.com.br

Journal of Pharmaceutical and Biomedical Analysis
|July 8, 2008
PubMed

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The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte properties and...