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Updated: Jul 3, 2026

Comet Assay as an Indirect Measure of Systemic Oxidative Stress
08:23

Comet Assay as an Indirect Measure of Systemic Oxidative Stress

Published on: May 22, 2015

Antioxidants and the Comet assay.

Eduardo Cemeli1, Adolf Baumgartner, Diana Anderson

  • 1University of Bradford, Division of Biomedical Sciences, Richmond Road, Bradford, West Yorkshire BD7 1DP, United Kingdom.

Mutation Research
|July 8, 2008
PubMed
Summary

Antioxidants protect health by neutralizing harmful radicals and safeguarding DNA. This review examines various antioxidants, including vitamins and polyphenols, assessing their dual roles in health and potential risks.

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Area of Science:

  • Biochemistry
  • Toxicology
  • Nutritional Science

Background:

  • Antioxidants, both internal and dietary, are crucial for health, combating oxidative stress and DNA damage.
  • The precise antioxidant mechanisms and identities of many compounds, especially from plant sources, remain unclear.
  • The Comet assay is a valuable tool for studying DNA damage and antioxidant effects.

Purpose of the Study:

  • To review the known antioxidant and prooxidant activities of various compounds.
  • To discuss the beneficial and non-beneficial properties of selected antioxidants.
  • To highlight the importance of understanding antioxidant functions in human health.

Main Methods:

  • Literature review of studies investigating antioxidant effects.
  • Analysis of data from Comet assay applications in antioxidant research.

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A High-Throughput Comet Assay Approach for Assessing Cellular DNA Damage
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A High-Throughput Comet Assay Approach for Assessing Cellular DNA Damage

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CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells
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CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells

Published on: October 18, 2014

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Last Updated: Jul 3, 2026

Comet Assay as an Indirect Measure of Systemic Oxidative Stress
08:23

Comet Assay as an Indirect Measure of Systemic Oxidative Stress

Published on: May 22, 2015

A High-Throughput Comet Assay Approach for Assessing Cellular DNA Damage
07:57

A High-Throughput Comet Assay Approach for Assessing Cellular DNA Damage

Published on: May 10, 2022

CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells
10:59

CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells

Published on: October 18, 2014

  • Consideration of in vitro, ex vivo, and in vivo evidence for antioxidant compounds.

    • Main Results:

    • Many well-known antioxidants, including vitamins, polyphenols, and enzymes, were examined.
    • Evidence for both beneficial and detrimental effects of certain antioxidants was discussed.
    • The review highlights the complexity of antioxidant actions and the need for further research.

    Conclusions:

    • Understanding the dual prooxidant/antioxidant nature of compounds is critical due to increasing human exposure.
    • Further research is needed to fully elucidate the roles and mechanisms of various antioxidants.
    • Accurate assessment of antioxidant properties is essential for health and safety evaluations.