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Updated: Jul 3, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

Fine-tuning serotonin2c receptor function in the brain: molecular and functional implications.

Kelly A Berg¹, William P Clarke, Kathryn A Cunningham

¹Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.

Neuropharmacology

|July 8, 2008

Summary

The serotonin 2C receptor (5-HT2CR) regulates brain excitability and dopamine function. Targeting this receptor offers potential for treating neuropsychiatric disorders like depression and Parkinson's disease.

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Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

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A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

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Published on: August 11, 2021

Area of Science:

Neuroscience
Pharmacology
Molecular Biology

Background:

The serotonin 2C receptor (5-HT2CR) is a 7-transmembrane-spanning receptor.
It exhibits unique properties including constitutive activity and RNA editing.
Widely expressed in the central nervous system, it regulates neuronal excitability.

Purpose of the Study:

To review the functional status of the central 5-HT2CR.
To highlight its regulatory properties, constitutive activity, and RNA editing.
To explore its therapeutic potential for neuropsychiatric disorders.

Main Methods:

Review of molecular, cellular, anatomical, biochemical, and behavioral studies.
Analysis of receptor function, including constitutive activity and RNA editing.
Evaluation of therapeutic strategies targeting 5-HT2CR.

Main Results:

5-HT2CR modulates dopamine neuron function.
Constitutive activity and RNA editing significantly impact 5-HT2CR function in vivo.
Inverse agonism represents a promising therapeutic avenue.

Conclusions:

The 5-HT2CR is a key regulator of central nervous system function.
Its unique properties present novel therapeutic opportunities.
Targeting 5-HT2CR offers potential for treating depression, schizophrenia, Parkinson's disease, and addiction.