Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cue-induced inhibitory control in forensic patients with alcohol use disorder: A link to criminal recidivism risk assessed by factor 2 psychopathy.

Addictive behaviors reports·2026
Same author

Longitudinal associations of DNA-methylation of OXT, SLC6A4 and NR3C1 genes with the treatment response in patients with depression.

Scientific reports·2026
Same author

Smartphone-based digital markers and clinical symptoms during therapy for Borderline Personality Disorder.

Internet interventions·2026
Same author

Shedding light on social dominance within the affective neuroscience personality scales.

Personality neuroscience·2026
Same author

Do we need animal models to better understand the molecular basis of internet use disorders?

Journal of behavioral addictions·2026
Same author

A dialectical perspective on smartphone use in borderline personality disorder: Communication fosters inner tension and dissociation, while entertainment provides momentary relief.

Comprehensive psychiatry·2026

Related Experiment Video

Updated: Jul 3, 2026

Using Nicotine in a Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition
06:12

Using Nicotine in a Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition

Published on: March 3, 2023

The BDNF Val66Met polymorphism and smoking.

Christian Montag1, Ulrike Basten, Christine Stelzel

  • 1Department of Psychology, University of Bonn, Kaiser-Karl-Ring 9, D-53111 Bonn, Germany. christian.montag@uni-bonn-diff.de

Neuroscience Letters
|July 8, 2008
PubMed
Summary
This summary is machine-generated.

This study investigated the link between a brain-derived neurotrophic factor (BDNF) gene variant and smoking behavior. Our findings did not replicate a previously reported association between the BDNF Val66Met polymorphism and smoking in German Caucasians.

More Related Videos

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
14:21

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Published on: August 6, 2013

Related Experiment Videos

Last Updated: Jul 3, 2026

Using Nicotine in a Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition
06:12

Using Nicotine in a Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition

Published on: March 3, 2023

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
14:21

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Published on: August 6, 2013

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Brain-derived neurotrophic factor (BDNF) is crucial for neuronal function and implicated in mood disorders.
  • A specific BDNF gene variant, Val66Met polymorphism, affects BDNF secretion and has been linked to smoking.
  • Previous research suggested an association between the 66Met allele and smoking in Caucasians.

Purpose of the Study:

  • To replicate the association between the BDNF Val66Met polymorphism and smoking.
  • To investigate this genetic link in a larger German Caucasian cohort.

Main Methods:

  • Genotyping of the BDNF Val66Met polymorphism in 614 German Caucasian participants.
  • Statistical analysis to assess the association between the polymorphism and smoking status.

Main Results:

  • No significant association was found between the BDNF Val66Met polymorphism and smoking in the study sample.
  • The previously reported link between the 66Met allele and smoking was not replicated.

Conclusions:

  • The BDNF Val66Met polymorphism does not appear to be associated with smoking behavior in the studied German Caucasian population.
  • Further research is needed to clarify the complex relationship between BDNF and smoking.