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Updated: Jul 3, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Cytotoxic, antioxidant activities and structure activity relationship of some newly synthesized terpenoidal
Abd El-Galil E Amr1, Korany A Ali, Mohamed M Abdalla
1Applied Organic Chemistry Department, National Research Centre, El Tahrir Street, Dokki, Cairo, Egypt. aamr1963@yahoo.com
Abstract:
The terpenoidal oxaliplatin derivatives (6) and (12) were newly synthesized using 2beta,3alpha-dihydroxy-11-oxo-18beta-olean-12-ene-30-oic acid (1) and 2alpha,2beta-dihydroxy-18beta-ursan-12-ene-28-oic acid (7) as starting materials. The synthesized compounds were evaluated for their cytotoxicity and antioxidant activities and were compared to Oxaliplatin and vitamin C as positive controls. Some of the compounds exhibited better cytotoxicity and antioxidant activities than the reference controls. The detailed synthesis, spectroscopic data, toxicity (LD(50)) and pharmacological screening for the synthesized compounds were reported.
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