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Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients

Bettina Bankier1, Justine Barajas, Abelardo Martinez-Rumayor

  • 1Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. bettina.bankier@meduniwien.ac.at

European Heart Journal
|July 8, 2008
PubMed

Insights

C-reactive protein (CRP) was linked to generalized anxiety disorder (GAD) in stable coronary heart disease (CHD) patients. Other psychiatric conditions and cardiac biomarkers showed no significant associations in this study.

Area of Science:

  • Cardiology
  • Psychiatry
  • Biomarkers

Background:

  • Major depressive disorder (MDD) and anxiety disorders are prevalent in patients with stable coronary heart disease (CHD).
  • Cardiac biomarkers like C-reactive protein (CRP), troponin T (TnT), and NT-proBNP may reflect underlying pathophysiological processes in CHD patients with mental health conditions.

Purpose of the Study:

  • To comprehensively evaluate the associations between MDD, anxiety disorder, and comorbid MDD/anxiety disorder with cardiac biomarkers in stable CHD patients.
  • To investigate the relationship between CRP, TnT, NT-proBNP, and psychiatric disorders in this population.

Main Methods:

  • A cross-sectional study of 120 stable CHD outpatients was conducted.
  • Psychiatric diagnoses were confirmed using the structured clinical interview for DSM-IV.
  • Binomial logistic regression analyses were performed to assess associations between biomarkers and psychiatric conditions.

Main Results:

  • C-reactive protein (CRP) was significantly associated with generalized anxiety disorder (GAD) (P=0.04) after adjusting for covariates.
  • Troponin T (TnT) showed associations with hyperlipidaemia, obesity history, and education level.
  • NT-proBNP was associated with type II diabetes (P=0.005).
  • Major depressive disorder (MDD) and comorbid MDD/anxiety disorder did not show significant associations with the studied biomarkers.

Conclusions:

  • C-reactive protein (CRP) is associated with generalized anxiety disorder (GAD) in stable coronary heart disease (CHD) patients.
  • The study highlights the specific link between CRP and GAD, suggesting potential inflammatory pathways involved.
Abstract

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