Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Antiepileptic Drugs: Potassium Channel Activators

Antiepileptic Drugs: Potassium Channel Activators

Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...

Antiepileptic Drugs: GABAergic Pathway Potentiators

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editing the Nepalese Journal of Ophthalmology: a voyage of five years.

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH·2013

Same author

Ophthalmic oncology in Nepal - an area requiring special attention.

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH·2013

Same author

Manuscript submission: expectations and constraints.

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH·2013

Same author

The burden of glaucoma in Nepal.

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH·2012

Same author

Structural, thermal, and fluorescence properties of Eu(DBM)(3)Phen(x) complex doped in PMMA.

The journal of physical chemistry. B·2010

Same author

Therapeutic management of canine atopic dermatitis by combination of pentoxifylline and PUFAs.

Journal of veterinary pharmacology and therapeutics·2010

Search research articles

Related Experiment Videos

Topiramate induced bilateral angle-closure glaucoma.

S K Singh¹, S S Thapa, B P Badhu

¹Mechi Eye Care Centre, Birtamod, Jhapa, Nepal. sanjaysinghnepal@yahoo.com

Kathmandu University Medical Journal (KUMJ)

|July 8, 2008

Summary

This summary is machine-generated.

Topiramate can cause severe eye problems like angle-closure glaucoma. Early detection and treatment, including stopping the medication, can successfully manage this serious ophthalmic side effect.

Related Experiment Videos

Area of Science:

Ophthalmology
Pharmacology

Background:

Topiramate is a widely prescribed antiepileptic and migraine prophylactic medication.
Ophthalmic side effects of topiramate, though rare, necessitate clinical awareness.

Observation:

A case of bilateral angle-closure glaucoma induced by topiramate is reported.
This represents the first such case documented in Nepal.

Findings:

Discontinuation of topiramate was crucial for management.
Combined therapy with anti-glaucoma medication and atropine eye drops led to successful resolution.

Implications:

Highlights the potential for severe ophthalmic complications with topiramate use.
Emphasizes the importance of prompt recognition and intervention for topiramate-induced glaucoma.
Contributes to the understanding of topiramate's adverse effect profile in clinical practice.