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Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

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Testosterone deficiency: a common, unrecognized syndrome.

Jacques L Tostain¹, François Blanc

¹University of Saint Etienne Medical School, Saint Etienne, France. jacques.tostain@chu-st-etienne.fr

Nature Clinical Practice. Urology

|July 8, 2008

Summary

Testosterone deficiency syndrome (TDS) is underdiagnosed and undertreated, affecting men aged 40-70. This review discusses diagnostic challenges for low testosterone levels and related symptoms.

Area of Science:

Endocrinology
Men's Health

Background:

Testosterone deficiency syndrome (TDS) presents with clinical signs and symptoms due to low testosterone.
Age-related decline in testosterone can cause ambiguous symptoms, potentially mistaken for aging or depression.
Low testosterone significantly impacts quality of life and organ system function.

Purpose of the Study:

To review the diagnostic challenges associated with Testosterone Deficiency Syndrome.
To highlight potential pitfalls in diagnosing both clinical and biochemical aspects of TDS.

Main Methods:

Literature review focusing on diagnostic criteria and prevalence studies of TDS.
Analysis of clinical and biochemical diagnostic challenges.

Main Results:

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TDS prevalence ranges from 6-9.5% in men aged 40-70, increasing to 15-30% in diabetic or obese men.
Less than 10% of men with TDS receive appropriate treatment.
Diagnostic ambiguity is common, particularly with age-related testosterone decline.

Conclusions:

TDS is frequently underdiagnosed and undertreated.
Accurate diagnosis requires careful consideration of both clinical presentation and testosterone levels.
Addressing diagnostic pitfalls is crucial for effective management of TDS.