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Updated: May 6, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

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APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication

Yanxing Han1, Xiaojun Wang, Ying Dang

  • 1Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America.

Plos Pathogens
|July 8, 2008
PubMed
Summary

APOBEC3G (A3G) and APOBEC3F (A3F) normally inhibit HIV-1, but not in CEM-T4 cells. These cells lack a crucial cofactor for A3G/A3F antiviral activity, revealing a new target for HIV-1 research.

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