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Related Concept Videos

Drugs Acting on Autonomic Ganglia: Stimulants01:23

Drugs Acting on Autonomic Ganglia: Stimulants


Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
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Related Experiment Video

Updated: Jul 3, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Initial nicotine sensitivity in humans as a function of impulsivity.

Kenneth A Perkins1, Caryn Lerman, Sarah B Coddington

  • 1Western Psychiatric Institute & Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. perkinska@upmc.edu

Psychopharmacology
|July 8, 2008
PubMed
Summary

Impulsivity traits like novelty seeking influence initial sensitivity to nicotine reward and reinforcement, with effects varying between men and women. This research explores how personality impacts early smoking experiences.

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Related Experiment Videos

Last Updated: Jul 3, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Measuring Delay Discounting in Humans Using an Adjusting Amount Task
07:47

Measuring Delay Discounting in Humans Using an Adjusting Amount Task

Published on: January 9, 2016

Area of Science:

  • Neuroscience
  • Psychology
  • Addiction Research

Background:

  • Impulsivity is linked to increased risk of nicotine dependence.
  • This may occur by heightening sensitivity to nicotine's rewarding effects during initial smoking.
  • Understanding these links is crucial for early intervention strategies.

Purpose of the Study:

  • To investigate how impulsivity characteristics affect acute sensitivity to nicotine reward and reinforcement.
  • To explore nicotine's effects on mood, physiology, and performance in relation to impulsivity.
  • To examine these relationships in young adult nonsmokers.

Main Methods:

  • 131 young adult nonsmokers participated in four sessions.
  • Nicotine nasal spray (0, 5, 10 microg/kg) doses were administered to assess dose-response effects.
  • Impulsivity was measured using self-report and computer-based tasks, with factors including novelty seeking and response disinhibition.

Main Results:

  • Novelty seeking showed sex-dependent associations with nicotine reinforcement and reward.
  • Response disinhibition related to reward and mood responses, also differing by sex.
  • Extraversion was inversely associated with nicotine reinforcement; other factors had minimal impact.

Conclusions:

  • Preliminary findings suggest impulsivity traits, particularly novelty seeking and response disinhibition, are linked to initial nicotine sensitivity.
  • These associations, including reward and reinforcement, may differ between males and females.
  • Further research is needed to confirm these sex-specific relationships.