Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Casares' map function: no need for a 'corrected' Haldane's map function.

Daniel E Weeks1, Xinyu Tang, Amy M Kwon

  • 1Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Crabtree Hall, Room A303, 130 DeSoto Street, Pittsburgh, PA 15261, USA. weeks@pitt.edu

Genetica
|July 8, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative central retinal artery occlusion after prone posterior cervical spine surgery treated with delayed hyperbaric oxygen therapy: a case report and targeted literature review.

BMC anesthesiology·2026
Same author

A proposed method for locating the tibial attachment for medial patellotibial ligament reconstruction: A cadaveric anatomical and imaging study.

Journal of experimental orthopaedics·2026
Same author

Incorporating dietary information to enhance polygenic prediction models with applications to body mass index and type 2 diabetes.

Genes & nutrition·2026
Same author

Goal-based action generalization does not increase incrementally with action prevalence: Evidence from event-related potentials and behavior.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2026
Same author

Therapeutic Potential of Cucurbitacin I in Colon Adenocarcinoma Is Mediated by Modulation of SDHA Expression.

Journal of cellular and molecular medicine·2026
Same author

Meta-analysis of over 8,000 individuals from Hawai'i and Samoa for genetic associations to cardiometabolic phenotypes.

medRxiv : the preprint server for health sciences·2026
Same journal

Morphological and COI-based identification of species of the Hawkmoth genus Theretra Hübner, 1819 (Lepidoptera: Sphingidae) from Himachal Pradesh, India.

Genetica·2026
Same journal

Advancing genetics and evolution: new Editors-in-Chief in Genetica.

Genetica·2026
Same journal

Origin and diversification of Altai osmans (Oreoleuciscus), Far Eastern phoxinin minnows (Rhynchocypris) and Far Eastern redfins (Tribolodon) of the Leuciscidae family (Actinopterygii): an example of evolutionary tempo variation?

Genetica·2026
Same journal

Chloroplast genome comparison, phylogeny, and molecular evolution of five endemic Potentilla (Rosaceae) species in Mongolia.

Genetica·2026
Same journal

Severe trauma and chronic stress: seeds and fruits of epigenetic sensitivity.

Genetica·2026
Same journal

Molecular evolution and antigenic mapping of classical swine fever virus: a comprehensive analysis of E2 genomic variability and selection dynamics.

Genetica·2026
See all related articles

A new study demonstrates that Casares' proposed "corrected" Haldane's map function is incorrect. This finding impacts genetic mapping by highlighting flaws in a commonly used genetic map function.

Area of Science:

  • Genetics
  • Bioinformatics
  • Statistical Genetics

Background:

  • Genetic map functions translate genetic distance to recombination fraction.
  • Recombination fractions are non-additive due to the nature of observed recombination events.
  • Haldane's map function, widely used since 1919, assumes no chiasma or chromatid interference.

Purpose of the Study:

  • To evaluate the validity of a recently proposed 'corrected' Haldane's map function.
  • To identify errors in the derivation and assumptions of the proposed corrected map function.

Main Methods:

  • Theoretical analysis of genetic map functions.
  • Examination of the assumptions underlying Haldane's map function and its proposed correction.
  • Mathematical derivation and critique of recombination fraction calculations.

Related Experiment Videos

Main Results:

  • The 'corrected' Haldane's map function proposed by Casares contains significant errors.
  • Faulty assumptions and derivation mistakes invalidate the proposed corrected map function.
  • The original Haldane's map function remains a subject of scrutiny regarding its underlying assumptions.

Conclusions:

  • The proposed 'corrected' Haldane's map function is not accurate and should not be used.
  • This study underscores the importance of rigorous derivation and assumption validation in genetic mapping.
  • Further research may be needed to refine genetic map functions for accurate genetic distance estimation.