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[Propranolol binding with plasma proteins and erythrocytes].
Farmakologiia I Toksikologiia
|January 1, 1991
Summary
Propranolol is significantly absorbed by red blood cells after oral administration in hypertensive patients. Measuring total and free propranolol in whole blood is recommended for accurate pharmacological assessment.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Biochemistry
Context:
- Hypertensive disease management.
- Oral administration of anapriline (80 mg).
- Study involved 12 patients.
Purpose:
- To investigate the binding of propranolol with plasma proteins and erythrocytes.
- To determine the distribution of propranolol in blood components.
- To recommend optimal methods for assessing propranolol's pharmacological parameters.
Summary:
- Propranolol exhibits significant binding to erythrocytes, with free form ratios to plasma content averaging 3.72 and 2.70 at 2 and 4 hours post-administration.
- Plasma protein binding of propranolol was found to be 0.84 +/- 0.4.
- Erythrocyte uptake of propranolol is substantial, influencing its distribution.
Impact:
- Highlights the importance of considering erythrocyte binding in propranolol pharmacokinetics.
- Suggests whole blood analysis for total and free propranolol is more informative than plasma analysis.
- Informs clinical practice for more accurate therapeutic drug monitoring in hypertensive patients.