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General zinc-catalyzed intermolecular hydroamination of terminal alkynes

Karolin Alex1, Annegret Tillack, Nicolle Schwarz

  • 1Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Rostock, Germany.

Chemsuschem
|July 9, 2008
PubMed

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One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.
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Introduction
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