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Related Concept Videos

Methods of Sterilization I: Physical Methods01:29

Methods of Sterilization I: Physical Methods

As used in a healthcare facility, sterilization destroys all microorganisms through physical or chemical methods. The physical method includes steam, dry heat, boiling water, and radiation.
Steam sterilization uses non-toxic, low-cost moist heat in the form of saturated steam under pressure, which is fast, microbicidal, and sporicidal, and quickly warms and penetrates fabrics. Autoclaves, or steam sterilizers, expose each item to direct steam contact for a predetermined time at the necessary...
Physical Methods for Controlling Microbial Growth: Radiation and Filtration01:26

Physical Methods for Controlling Microbial Growth: Radiation and Filtration

Radiation and filtration are essential tools for microbial control, targeting microorganisms through distinct mechanisms. Radiation eliminates microbes by damaging their DNA, either killing them or inhibiting their growth. Based on wavelength, radiation is classified into two types: nonionizing and ionizing radiation.Non-ionizing radiation, such as UV radiation (200–400 nm), is absorbed by DNA, causing defects that effectively disinfect surfaces, air, and water, including safety cabinets.
Methods of Sterilization II: Chemical Methods01:30

Methods of Sterilization II: Chemical Methods

In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
Physical Methods for Controlling Microbial Growth: Temperature01:23

Physical Methods for Controlling Microbial Growth: Temperature

Heat is a widely used method to control microbial growth by targeting and denaturing cellular proteins, thereby killing or inactivating microbes. This method's effectiveness is quantified using parameters such as the thermal death point (TDP), thermal death time (TDT), and decimal reduction time (D value). TDP represents the lowest temperature at which all microorganisms in a liquid suspension are eliminated within 10 minutes, whereas TDT is the time necessary to achieve sterilization at a...
Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...

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Updated: Jul 3, 2026

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts
08:17

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts

Published on: April 14, 2023

Developments in radiation sterilisation.

R Brinston1, A Miller, C Deeley

  • 1iiA, Ottawa, Ottawa, Canada. ruth.briston@doubleia.org

Medical Device Technology
|July 9, 2008
PubMed
Summary

This article details advancements in radiation sterilization, focusing on a new method for combination products and updated guidelines for sterility assurance levels. These developments aim to improve safety and efficacy in medical device sterilization.

Area of Science:

  • Medical device sterilization
  • Radiation sterilization technologies

Background:

  • Radiation sterilization is a critical process for medical devices.
  • Ensuring product safety requires adherence to evolving sterilization guidelines.

Purpose of the Study:

  • To outline recent developments in radiation sterilization.
  • To highlight ongoing initiatives in sterilization technology and guidelines.

Main Methods:

  • Review of current radiation sterilization advancements.
  • Analysis of revisions to sterilization guidelines.
  • Investigation of methods for sterilizing combination products.

Main Results:

  • Significant progress has been made in radiation sterilization techniques.

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The Portable Chemical Sterilizer (PCS), D-FENS, and D-FEND ALL: Novel Chlorine Dioxide Decontamination Technologies for the Military
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The Portable Chemical Sterilizer (PCS), D-FENS, and D-FEND ALL: Novel Chlorine Dioxide Decontamination Technologies for the Military

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Standardized Method for High-throughput Sterilization of Arabidopsis Seeds
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Standardized Method for High-throughput Sterilization of Arabidopsis Seeds

Published on: October 17, 2017

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Last Updated: Jul 3, 2026

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts
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Published on: April 14, 2023

The Portable Chemical Sterilizer (PCS), D-FENS, and D-FEND ALL: Novel Chlorine Dioxide Decontamination Technologies for the Military
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Standardized Method for High-throughput Sterilization of Arabidopsis Seeds

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  • New approaches for sterilizing combination products are being developed.
  • Sterilization guidelines are being updated, including those for sterility assurance levels.

    • Conclusions:

    • The field of radiation sterilization is actively advancing.
    • Updated guidelines and methods will enhance the safety and reliability of medical device sterilization.