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Lung tumors with neuroendocrine morphology: essential radiologic and pathologic features
Teri J Franks1, Jeffrey R Galvin
1Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA. frankst@afip.osd.mil
Context:
Tumors with neuroendocrine morphology are a distinct subset of lung neoplasms sharing characteristic histologic, immunohistochemical, ultrastructural, and molecular features.
Objective:
To review the current histologic classification and the diagnostic criteria for the major categories of neuroendocrine tumors of the lung.
Data Sources:
Published classification systems from the World Health Organization and pertinent peer-reviewed articles indexed in PubMed (National Library of Medicine) form the basis of this review.
Conclusions:
Accurate classification of the neuroendocrine tumors of the lung requires knowledge of specific criteria separating the major categories, which is essential for determining prognosis and treatment.