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Published on: February 10, 2020
Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
Bernard M Y Cheung1, Kwok Leung Ong, Roberta V Cheung
1Department of Medicine, University of Hong Kong, Hong Kong. b.cheung@bham.ac.uk
Background:
Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population.
Methods:
Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2+/-11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort.
Results:
The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (beta=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (beta=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels.
Conclusions:
ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study.
