Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunomodulating activity of heparin.

A Górski1, M Wasik, M Nowaczyk

  • 1Department of Immunology, Warsaw Medical School, Poland.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|June 1, 1991
PubMed
Summary

Low dose heparin exhibits immunomodulatory effects beyond anticoagulation. It impacts lymphocyte traffic by inhibiting heparanase and demonstrates immunosuppressive actions, with varying effects based on administration route.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magnetic Circular Dichroism of <i>meso</i>-Phenyl-Substituted Pd-Octaethylporphyrins.

The journal of physical chemistry. A·2020
Same author

Therapeutic potential of phages in autoimmune liver diseases.

Clinical and experimental immunology·2017
Same author

Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Activity of Zn and Mg phthalocyanines and porphyrazines in amyloid aggregation of insulin.

Journal of molecular recognition : JMR·2017
Same author

Resonance Raman spectroscopy study of protonated porphyrin.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2016
Same author

Pathologies in Living Kidney Donors Diagnosed in the Long-Term Care System.

Transplantation proceedings·2016

Area of Science:

  • Immunology
  • Pharmacology
  • Biochemistry

Background:

  • Heparin is primarily known for its anticoagulant properties.
  • Emerging research highlights heparin's diverse biological activities.
  • Low-dose heparin's role in immune modulation is gaining attention.

Purpose of the Study:

  • To investigate the immunomodulatory effects of low-dose heparin.
  • To elucidate the mechanisms underlying heparin's impact on immune cells.
  • To compare the immunosuppressive potential of different heparin administration routes.

Main Methods:

  • Analysis of lymphocyte traffic and heparanase expression.
  • In vitro and in vivo assessment of immunosuppressive activity.
  • Comparative study of oral versus subcutaneous heparin administration.

Related Experiment Videos

Main Results:

  • Low-dose heparin modulates lymphocyte migration by blocking heparanase.
  • Heparanase inhibition affects extracellular matrix digestion and cell penetration.
  • Heparin exhibits a weak direct immunosuppressive effect in vitro and in vivo.
  • Oral heparin administration results in weaker immunosuppression compared to subcutaneous administration.

Conclusions:

  • Heparin possesses significant immunomodulatory properties independent of its anticoagulant function.
  • The inhibition of heparanase is a key mechanism for heparin's effect on lymphocyte trafficking.
  • Administration route influences the degree of immunosuppression induced by heparin.