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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

A novel diversion protocol dramatically reduces diversion hours.

Osei Kwame Asamoah1, Steven J Weiss, Amy A Ernst

  • 1Department of Emergency Medicine, University of New Mexico, Albuquerque, NM 87131-0001, USA.

The American Journal of Emergency Medicine
|July 9, 2008
PubMed
Summary
This summary is machine-generated.

A new ambulance diversion policy significantly reduced hospital diversion hours but increased emergency medical service (EMS) drop-off times. This change impacted patient care timelines in a large community.

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Area of Science:

  • Emergency Medicine
  • Healthcare Policy
  • Public Health

Background:

  • Ambulance diversion poses a significant challenge in many communities, potentially delaying critical medical care for patients.
  • This study addresses the impact of ambulance diversion on patient care timeliness.

Purpose of the Study:

  • To compare ambulance diversion hours and emergency medical service (EMS) drop-off times before and after implementing a restrictive diversion policy.
  • The policy limited hospital diversion to 1 hour out of every 8.

Main Methods:

  • A retrospective study was conducted in a county with 10 hospitals over 18 months (September 2004 to February 2006).
  • A countywide ambulance diversion protocol was implemented in March 2005.
  • Ambulance diversion hours and EMS drop-off times were compared across pretrial, interim, and posttrial periods using ANOVA and Tukey post hoc analysis.

Main Results:

  • The new protocol significantly decreased monthly ambulance diversion hours by 251 hours (to 18% of pretrial levels).
  • A significant increase in EMS drop-off times (by 178 hours) was observed.
  • No significant difference in monthly patient transports was noted between periods.

Conclusions:

  • The implemented ambulance diversion protocol effectively reduced diversion hours.
  • This reduction in diversion came at the expense of increased EMS drop-off times.
  • The findings suggest a trade-off between diversion reduction and patient transport efficiency.