Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microbial Classification System

Microbial Classification System

Classification is the process of organizing organisms into hierarchically inclusive groups based on their phenotypic similarities or evolutionary relationships. A species comprises one or more strains, and closely related species are grouped into genera. Genera are further classified into families, families into orders, orders into classes, and so forth, up to the domain level, which is the broadest taxonomic rank derived from a combination of phenotypic and genotypic data.The nomenclature of...

Automated Microbial Diagnostics

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

Rapid Identification of Pathogens

Rapid Identification of Pathogens

MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

Microbiota of the Urogenital Tract

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Artificial intelligence enables scale, consistency, and rigor in forensic identity inference.

Croatian medical journal·2026

Same author

Terminology, retrieval bias, and field definition in forensic genetic genealogy.

Forensic science international. Synergy·2026

Same author

Large-scale analysis of DNA quantification metrics and SNP sequencing performance in unidentified human remains.

Forensic science international. Genetics·2026

Same author

Othram maps: a graph-powered platform for pedigree visualization and forensic intelligence.

Bioinformatics (Oxford, England)·2026

Same author

On the uncertainty associated with using a signal detection theory model to analyze data from forensic black-box studies.

Forensic science international·2026

Same author

Animal Species and Identity Testing: Developments, Challenges, and Applications to Non-Human Forensics.

Genes·2025

Same journal

Cross-sectional blood vessel area differences in various causes of death in unenhanced forensic post-mortem computed tomography.

International journal of legal medicine·2026

Same journal

Diagnostic performance of Demirjian's third molar maturation stages G, G1, and H for identifying the 18-year age threshold: a sex-specific study.

International journal of legal medicine·2026

Same journal

Environmental DNA (eDNA) from humans: Review of recent advancements and forensic implications.

International journal of legal medicine·2026

Same journal

Joint editorial: shared deliberations of the editors-in-chief of three forensic journals regarding ethical issues in forensic publishing.

International journal of legal medicine·2026

Same journal

Dental age assessment: orthopantomogram-based comparison of traditional methods and artificial intelligence in the adult population.

International journal of legal medicine·2026

Same journal

Sex estimation from morphometry of lumbar vertebrae (L4-L5): A machine learning approach.

International journal of legal medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Published on: July 11, 2016

The Microbial Rosetta Stone: a database system for tracking infectious microorganisms.

Kumar L Hari¹, Alan T Goates, Ravi Jain

¹Ibis Biosciences, 1891 Rutherford Rd., Carlsbad, CA 92008, USA.

International Journal of Legal Medicine

|July 9, 2008

Summary

This summary is machine-generated.

The Microbial Rosetta Stone (MRS) database supports law enforcement with integrated microbial pathogen data. It aids investigations by connecting diverse data on microbes and toxins for biocrime and bioterrorism threats.

More Related Videos

Direct Microbial Identification using An Automated Microbial Identification System to Facilitate the EUCAST RAST Method Without Mass Spectrometry

Direct Microbial Identification using An Automated Microbial Identification System to Facilitate the EUCAST RAST Method Without Mass Spectrometry

Published on: May 24, 2024

Related Experiment Videos

Last Updated: Jul 3, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Published on: July 11, 2016

Direct Microbial Identification using An Automated Microbial Identification System to Facilitate the EUCAST RAST Method Without Mass Spectrometry

Direct Microbial Identification using An Automated Microbial Identification System to Facilitate the EUCAST RAST Method Without Mass Spectrometry

Published on: May 24, 2024

Area of Science:

Microbiology
Bioinformatics
Forensic Science

Background:

Law enforcement and intelligence agencies require comprehensive microbial pathogen data for investigations.
Existing data systems were insufficient for the diverse information needed for biocrime and bioterrorism analysis.

Purpose of the Study:

To develop the Microbial Rosetta Stone (MRS) database system.
To create a connected repository of microbial pathogen data for law enforcement and intelligence communities.

Main Methods:

Enhanced an existing data model for medical and epidemiological information.
Integrated expert-curated microbial pathogen data, including priority lists, sequence metadata, taxonomy, diseases, detection protocols, and experimental results.
Developed software tools for data loading, curation, and connection.

Main Results:

The MRS database provides a comprehensive and connected repository of microbial pathogen information.
The system supports real-time data population by multiple users across different locations.
Querying tools offer powerful access to the integrated data.

Conclusions:

The MRS database system is a valuable resource for law enforcement and intelligence agencies.
It enhances the ability to investigate biocrime and bioterrorism events through accessible, curated microbial data.
Continuous data collection and updating are essential for maintaining the system's utility.