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Electrocardiogram changes during intrauterine injection of ionic contrast medium.
Investigative Radiology
|June 1, 1991
Summary
Hysterosalpingography using meglumine-sodium diatrizoate caused significant QTc prolongation in most women. This electrocardiogram effect was temporary, resolving within minutes, and its mechanism remains unknown.
Area of Science:
- Cardiology
- Radiology
- Gynecology
Background:
- Hysterosalpingography is a common gynecological imaging procedure.
- The use of contrast media during the procedure may have physiological effects.
Purpose of the Study:
- To evaluate the effect of intrauterine meglumine-sodium diatrizoate 60% on electrocardiogram (ECG) parameters.
- To assess potential cardiac changes during hysterosalpingography.
Main Methods:
- Twenty-eight healthy women undergoing hysterosalpingography were studied.
- Electrocardiograms were monitored before and after the injection of meglumine-sodium diatrizoate 60% contrast medium.
- Saline injections were administered to a subset of patients to control for mechanical effects.
Main Results:
- A significant prolongation of the QTc interval was observed in 90% of women (25 out of 28).
- The mean QTc interval increased from 417 ms to 451 ms (P < .001).
- This QTc prolongation was transient, resolving within 2-3 minutes post-injection. Saline injection did not cause significant QTc changes.
Conclusions:
- Intrauterine injection of meglumine-sodium diatrizoate 60% can cause transient QTc prolongation.
- The exact mechanism underlying this observed electrocardiographic effect is currently unknown.
- Further research is needed to elucidate the mechanism and clinical significance of this finding.