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Updated: Oct 17, 2026

Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity
Published on: February 16, 2017
Novel interactions of TG2 with heparan sulfate proteoglycans: reflection on physiological implications
E A M Verderio1, A Scarpellini, T S Johnson
1School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, UK. elisabetta.verderio-edwards@ntu.ac.uk
Abstract:
This mini-review brings together information from publications and recent conference proceedings that have shed light on the biological interaction between transglutaminase-2 and heparan sulphate proteoglycans. We subsequently draw hypotheses of possible implications in the wound healing process. There is a substantial overlap in the action of transglutaminase-2 and the heparan sulphate proteoglycan syndecan-4 in normal and abnormal wound repair. Our latest findings have identified syndecan-4 as a possible binding and signalling partner of fibronectin-bound TG2 and support the idea that transglutaminase-2 and syndecan-4 act in synergy.
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