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Activation of vocal fold healing with topical vitamin A in rabbits
Ozgur Akdogan1, Adin Selcuk, Ibrahim Ozcan
1Ankara Numune Education and Research Hospital, 4th ENT Clinic, Attending Otolaryngolog Ankara, Ankara, Turkey. drozgurakdogan@gmail.com
Conclusion:
The results suggest that vitamin A can prevent scar formation in the vocal fold after surgery.
Objectives:
This study aimed to evaluate the effects of topically applied vitamin A on healing after vocal fold trauma.
Materials And Methods:
Vocal folds of 20 adult rabbits were traumatized unilaterally. Ten of them were treated with topical application of vitamin A and the others served as controls. All animals were sacrificed after 10 days. Vocal folds were resected for analysis by light microscopy.
Results:
The untreated vocal folds showed extensive deposition of collagen and fibroblast on light microscopy and vocal folds treated with vitamin A showed less deposition. There was a significant difference between the two groups according to the percentage of collagen and fibroblasts in the lamina propria (p<0.01).
