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Updated: Jul 3, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Published on: March 16, 2018

Ototoxic interaction of kanamycin and 3-nitropropionic acid

Chia-Der Lin1, Takeshi Oshima, Kiyoshi Oda

  • 1Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Acta Oto-Laryngologica
|July 9, 2008
PubMed
Summary

Mitochondrial dysfunction exacerbates aminoglycoside ototoxicity. Combining a mitochondrial toxin with kanamycin significantly increased hearing loss and hair cell damage in guinea pigs.

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