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ALSOD: the Amyotrophic Lateral Sclerosis Online Database.

Richard Wroe1, Amy Wai-Ling Butler, Peter M Andersen

  • 1Department of Neuroscience, MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK.

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
|July 9, 2008
PubMed
Summary

The Amyotrophic Lateral Sclerosis Database (ALSOD) has been updated to link SOD1 gene mutations to protein structure changes and ALS symptoms. This enhanced database provides a comprehensive resource for ALS genetic, proteomic, and bioinformatics research.

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Area of Science:

  • Neuroscience
  • Genetics
  • Bioinformatics

Background:

  • Over 100 point mutations in the SOD1 gene are linked to Amyotrophic Lateral Sclerosis (ALS).
  • The Amyotrophic Lateral Sclerosis Database (ALSOD) was established in 1999 to correlate SOD1 genotype with ALS phenotype.
  • Previous versions of ALSOD facilitated data storage and retrieval for ALS research.

Purpose of the Study:

  • To report the ongoing development and redesign of the ALSOD database.
  • To enhance the database with new features for improved data analysis and accessibility.
  • To strengthen the link between SOD1 mutations, protein structure, and the ALS clinical presentation.

Main Methods:

  • Redesign and redevelopment of the ALSOD database architecture.
  • Implementation of automated procedures for data management and analysis.
  • Integration of genetic, proteomic, and bioinformatics data related to SOD1 and ALS.

Main Results:

  • Significant improvements in ALSOD's functionality and data integration capabilities.
  • Enhanced ability to connect SOD1 mutations to hypothetical three-dimensional protein structural rearrangements.
  • Improved correlation between SOD1 genotype and ALS phenotype through updated data and analysis.
  • ALSOD now serves as a more comprehensive knowledge base for ALS.

Conclusions:

  • The redesigned ALSOD database offers a more powerful tool for ALS research.
  • The enhanced features facilitate a deeper understanding of SOD1's role in ALS pathogenesis.
  • ALSOD provides valuable genetic, proteomic, and bioinformatics information for the ALS research community.