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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Related Experiment Video

Updated: Jul 3, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

High-density lipoprotein: a fall from grace?

Sander I van Leuven1, Erik S Stroes, John J P Kastelein

  • 1Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. s.i.vanleuven@amc.uva.nl

Annals of Medicine
|July 9, 2008
PubMed
Summary

High-density lipoprotein cholesterol (HDL) was thought to prevent atherosclerosis. However, recent trials challenge this, suggesting a need to re-evaluate HDL

Area of Science:

  • Cardiovascular Research
  • Lipid Metabolism
  • Pharmacology

Background:

  • High-density lipoprotein cholesterol (HDL) has been traditionally considered atheroprotective.
  • Pharmacological elevation of HDL is a potential strategy for atherosclerotic vascular disease.
  • Cholesteryl ester transfer protein (CETP) inhibition was a promising therapeutic target.

Purpose of the Study:

  • To discuss recent developments impacting the HDL hypothesis.
  • To explore emerging therapeutic strategies in the HDL field.

Main Methods:

  • Review of in-vitro and in-vivo research data.
  • Analysis of results from four large clinical trials involving CETP inhibitors.
  • Discussion of evolving understanding of HDL function.

Related Experiment Videos

Last Updated: Jul 3, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Main Results:

  • Recent clinical trials with CETP inhibitors yielded disappointing results, necessitating a refinement of the HDL hypothesis.
  • Emerging evidence suggests HDL functions as a carrier for various proteins, not solely cholesterol.
  • Focus is shifting beyond solely measuring HDL levels.

Conclusions:

  • The traditional view of HDL as universally atheroprotective requires re-evaluation.
  • Future therapeutic strategies may need to consider HDL's broader role beyond cholesterol transport.
  • Further research into HDL's complex functions is warranted for effective cardiovascular disease treatment.