Subcutaneous silicone injection leading to multi-system organ failure

Area of Science:

• Medical Case Reports
• Toxicology
• Cosmetic Procedures

Background:

• Silicone is a durable, thermally stable liquid polymer frequently used in cosmetic procedures.
• Potential for end-organ toxicity exists following silicone injections.
• This report details two cases of multiorgan dysfunction after silicone injection.

Observation:

• Two male patients received 1-2 liters of subcutaneous silicone injections in the hips and buttocks.
• Both presented with altered consciousness, nausea, lethargy, tachycardia, hypotension, and hypoxia.
• Radiographs showed progressive adult respiratory distress syndrome (ARDS).

Findings:

• Despite medical intervention, one patient developed fatal respiratory failure with ARDS and silicone emboli to the brain.
• The second patient recovered after several days.
• Autopsy revealed organizing pneumonia, ARDS, and foreign body giant cell reactions to silicone.

Implications:

• Clandestine silicone injections for body enhancement carry significant risks.
• Healthcare providers should be aware of the potential for severe complications.
• Early recognition and management are crucial for patient outcomes.