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Oral tetridamine exposures.

Salomé Ballesterosé¹, María Fátima Ramón, Rosa Martínez-Arrieta

¹Spanish Poison Control Centre, Instituto de Toxicología y Ciencias Forenses, Madrid, Spain. s.ballesteros@mju.es

Clinical Toxicology (Philadelphia, Pa.)

|July 9, 2008

Summary

This study reports the first cases of tetridamine overdose, primarily due to accidental ingestion of vaginal preparations. Most patients experienced gastrointestinal symptoms, highlighting the need for clear usage instructions for topical medications.

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Area of Science:

Pharmacology
Toxicology
Clinical Medicine

Background:

Tetridamine is a topical non-steroidal anti-inflammatory drug (NSAID) from the indazole class, used as an adjunct treatment for vaginitis.
No prior data existed regarding tetridamine overdoses or toxicity.

Purpose of the Study:

To analyze the clinical effects and circumstances of tetridamine overdoses.
To establish the initial data on tetridamine toxicity following ingestion.

Main Methods:

A retrospective analysis was conducted on single ingestions of tetridamine vaginal douches.
Data were collected from the Spanish Poison Control Centre between January 1991 and December 2003.

Main Results:

Seventy-seven cases were analyzed, with most patients being adult females.
Accidental ingestion, often mistaking the vaginal douche for an oral preparation, was the primary cause (87%).
Gastrointestinal symptoms (vomiting, nausea, abdominal pain) were most common; one case of coma occurred after a 4g ingestion.

Conclusions:

This study presents the first documented cases of tetridamine overdose.
Physicians and pharmacists should emphasize correct usage of vaginal preparations to prevent accidental ingestion.