Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety and tolerability of Pau d' Arco (<i>Tabebuia avellanedae)</i> for primary dysmenorrhea: A single-arm, open-label trial on adults ages 18-45.

Advances in integrative medicine·2023
Same author

'PDSAFE' - a multi-dimensional model of falls-rehabilitation for people with Parkinson's. A mixed methods analysis of therapists' delivery and experience.

Physiotherapy·2020
Same author

A randomized controlled feasibility trial exploring partnered ballroom dancing for people with Parkinson's disease.

Clinical rehabilitation·2017
Same author

Fall frequency, predicting falls and participating in falls research: similarities among people with Parkinson's disease with and without cognitive impairment.

Parkinsonism & related disorders·2014
Same author

Sequence and onset of whole-body coordination when turning in response to a visual trigger: comparing people with Parkinson's disease and healthy adults.

Gait & posture·2013
Same author

Resuming previously valued activities post-stroke: who or what helps?

Disability and rehabilitation·2009

Related Experiment Video

Updated: Jul 3, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Dysfunctional turning in Parkinson's disease.

E Stack1, A Ashburn

  • 1School of Health Professions & Rehabilitation Science, University of Southampton, UK.

Disability and Rehabilitation
|July 9, 2008
PubMed
Summary

People with Parkinson's disease (PD) exhibit significant turning asymmetry and difficulty compared to healthy individuals. This turning impairment, particularly left-right asymmetry, correlates with PD severity and may indicate a need for rehabilitation.

Area of Science:

  • Neurology
  • Movement Disorders
  • Biomechanical Analysis

Background:

  • Turning is a fundamental daily activity that is frequently impaired in individuals with Parkinson's disease (PD).
  • Impaired turning in PD can manifest as freezing or falling, impacting independence and quality of life.
  • Understanding the specific characteristics of turning deficits in PD is crucial for developing targeted interventions.

Purpose of the Study:

  • To comprehensively describe turning differences between individuals with and without PD.
  • To investigate the extent of left-right asymmetry during turning in PD.
  • To explore correlations between turning parameters, age, balance, and PD severity using a clinical test.

Main Methods:

  • A video-based Standing Start 180 degrees Turn Test was administered to 28 individuals with PD and 12 controls.

More Related Videos

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model
05:38

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jul 3, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model
05:38

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model

Published on: January 7, 2019

  • Key turning parameters measured included step count, time, and quality (rated 0-5).
  • Left-right turning agreement was assessed using 95% limits.
  • Main Results:

    • Individuals with PD showed significantly more steps, longer turn times, and lower turn quality compared to controls (p < 0.004).
    • Marked left-right asymmetry in turning was observed in the PD group, with 75% turning 'on-the-spot'.
    • Turning step count strongly correlated with self-assessed disability in PD (r=0.67) and age in controls (r=0.87).

    Conclusions:

    • Difficulty with turning is prevalent in Parkinson's disease and likely impacts daily activities, suggesting potential benefits from rehabilitation.
    • Directional asymmetry in turning is a readily identifiable characteristic in PD.
    • Further research into the diagnostic value of turning asymmetry in Parkinson's disease is warranted.