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In Vivo Imaging and Tracking of Technetium-99m Labeled Bone Marrow Mesenchymal Stem Cells in Equine Tendinopathy
Published on: December 9, 2015
Mesenchymal stem cell therapy for equine tendinopathy.
1Department of Veterinary Clinical Sciences, The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire, UK. rksmith@rvc.ac.uk
Disability and Rehabilitation
|July 9, 2008
Summary
Marrow-derived stromal stem cells (BM-MSCs) implantation in horses with tendon injuries reduced re-injury rates compared to conventional methods. This regenerative approach shows promise for improving equine athlete recovery and performance.
Area of Science:
- Veterinary Medicine
- Regenerative Medicine
- Equine Sports Medicine
Background:
- Tendon overuse injuries in athletes often lead to scar tissue formation, hindering recovery and increasing re-injury risk.
- Optimal management strategies aim to regenerate normal tendon matrix and reduce re-injury rates.
Purpose of the Study:
- To review the clinical technique and outcome data for autologous bone marrow-derived stromal stem cell (BM-MSC) implantation in horses with superficial digital flexor tendon (SDFT) injuries.
- To evaluate the efficacy of BM-MSC therapy in promoting tendon healing and return to performance.
Main Methods:
- Bone marrow was aspirated from the sternum, and nucleated adherent cells (BM-MSCs) were isolated and expanded.
- Expanded BM-MSCs were implanted into injured SDFTs under ultrasonographic guidance.
- Horses underwent a 48-week rehabilitation program with an ascending exercise regime.
Main Results:
- 168 racehorses were treated by September 2006.
- 18% of treated horses re-injured after returning to full work, a lower rate than the 56% seen in conventional management studies.
- No adverse effects were observed apart from needle tracts.
Conclusions:
- Autologous BM-MSC implantation may improve clinical outcomes for equine tendon injuries.
- Further randomized controlled trials are required to definitively prove the efficacy of this regenerative approach.
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