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Related Experiment Video

Updated: Jul 3, 2026

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

Achilles tendon problems: not just an orthopaedic issue.

Paul Richard Julian Ames¹, Umile Giuseppe Longo, Vincenzo Denaro

¹Immunoclot Ltd, Leeds, UK.

Disability and Rehabilitation

|July 9, 2008

Summary

Achilles tendon issues extend beyond overuse injuries. This review highlights that Achilles tendon problems can stem from inflammatory, autoimmune, genetic, infectious, neoplastic, and neurological conditions, not just surgical causes.

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Last Updated: Jul 3, 2026

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

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Published on: March 1, 2024

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

Published on: December 8, 2023

Area of Science:

Orthopedics
Rheumatology
Pathology

Background:

Achilles tendon pathologies are commonly attributed to overuse or acute injuries in active individuals.
A broader range of underlying conditions may contribute to Achilles tendon dysfunction.

Purpose of the Study:

To comprehensively review current understanding of Achilles tendon involvement in diverse pathological states.
To expand the differential diagnosis for Achilles tendon complaints beyond common etiologies.

Main Methods:

A systematic literature search was performed to identify relevant studies.
The search focused on Achilles tendon pathology within the context of general medical conditions.

Main Results:

The Achilles tendon can be affected by inflammatory and autoimmune diseases.
Genetic collagen abnormalities, infections, tumors, and neurological disorders can also manifest with Achilles tendon involvement.
These conditions are often non-surgical in nature.

Conclusions:

Achilles tendon problems are not exclusively linked to athletic overuse or acute trauma.
A variety of systemic and local pathological conditions should be considered in the differential diagnosis of Achilles tendon issues.