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Cognitive deficits in essential tremor consistent with frontosubcortical dysfunction.

Christopher I Higginson1, Vicki L Wheelock, Dawn Levine

  • 1Department of Psychology, Loyola College in Maryland, Baltimore, MD 21210-2699, USA. cihigginson@loyola.edu

Journal of Clinical and Experimental Neuropsychology
|July 9, 2008
PubMed
Summary

Essential tremor (ET) patients show cognitive deficits similar to Parkinson's disease (PD) patients. Both groups performed worse than healthy controls, suggesting frontosubcortical dysfunction in ET.

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Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Essential tremor (ET) is a heterogeneous condition.
  • Some ET patients exhibit Parkinson's disease (PD) symptoms, including cognitive impairment.

Purpose of the Study:

  • To compare cognitive function in ET, PD, and control groups.
  • To investigate potential frontosubcortical dysfunction in Essential Tremor.

Main Methods:

  • Neuropsychological assessment of 33 ET patients, 33 PD patients, and 21 normal controls.
  • Utilized a broad battery of cognitive tests.

Main Results:

  • ET patients performed significantly worse than controls across multiple cognitive domains.
  • Cognitive performance in ET patients was remarkably similar to PD patients.
  • Findings suggest frontosubcortical dysfunction in Essential Tremor.

Conclusions:

  • Essential tremor may share underlying neuropathological mechanisms with Parkinson's disease.
  • Cognitive deficits are prevalent in Essential Tremor and resemble those seen in Parkinson's disease.