Age, family history, and memory and future risk for cognitive impairment
Dona E C Locke1, Robert J Ivnik, Ruth H Cha
1Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, AR 85259, USA. locke.dona@mayo.edu
Purpose:
To provide a clinical tool for calculating a patient's future risk for developing cognitive impairment based on age, family history, and Rey Auditory Verbal Learning Test (AVLT) retention.
Participants:
1,019 cognitively normal persons followed for an average of 5 years; 159 participants were eventually diagnosed with cognitive impairment.
Results:
Risk of developing cognitive impairment increases with age and family history, but decreases with better memory performance. A nomogram is provided for calculation of relative risk of developing cognitive impairment in combinations of age, family history, and memory performance.
Conclusions:
These results enhance clinicians' ability to provide information to a patient about risk of cognitive impairment.
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