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Related Experiment Video

Updated: Jul 3, 2026

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Published on: January 26, 2024

Age-related neural activity during allocentric spatial memory.

E Antonova¹, D Parslow, M Brammer

¹Institute of Psychiatry, King's College London, UK. e.antonova@iop.kcl.ac.uk

Memory (Hove, England)

|July 9, 2008

Summary

This summary is machine-generated.

Healthy aging impairs spatial memory by reducing activity in the hippocampus and prefrontal cortex. This decline is linked to structural changes in these brain regions, affecting memory performance.

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The (Spatial) Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

The (Spatial) Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

Published on: February 19, 2018

Area of Science:

Neuroscience
Cognitive Psychology
Gerontology

Background:

Age-related spatial memory decline is a common observation across species.
Understanding the neural mechanisms underlying this decline is crucial for developing interventions.

Purpose of the Study:

To investigate the effects of healthy aging on neural activity during allocentric spatial memory tasks.
To examine the relationship between brain structure and function in aging individuals with spatial memory deficits.

Main Methods:

Utilized a virtual reality Morris Water Maze analogue to assess spatial memory.
Employed functional magnetic resonance imaging (fMRI) to measure neural activity.
Applied voxel-based morphometry to evaluate hippocampal and surrounding grey matter volume.

Main Results:

Both young and older adults activated a widespread neural network, including frontal, parietal, and cerebellar regions.
Young adults showed significantly greater activation in the bilateral hippocampus and left parahippocampus during encoding.
Older adults exhibited reduced activation in prefrontal and parahippocampal regions, correlated with volumetric reductions in these areas.

Conclusions:

The decline in allocentric spatial memory with age is associated with attenuated hippocampal function.
Compromised function and structure in prefrontal and parahippocampal regions contribute to age-related spatial memory deficits.