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Left ventricular diastolic function in patients with treated haemochromatosis
Einar Skulstad Davidsen1, Per Omvik, Tor Hervig
1Department of Heart Disease, Haukeland University Hospital, Norway. einar.davidsen@helse-bergen.no
Scandinavian Cardiovascular Journal : SCJ
|July 9, 2008
Summary
Genetic hemochromatosis patients show mildly impaired diastolic function, particularly delayed relaxation in younger individuals and elevated filling pressures with age, despite treatment.
Area of Science:
- Cardiology
- Genetics
- Internal Medicine
Background:
- Reduced exercise capacity is observed in phlebotomy-treated genetic hemochromatosis patients, even with normal systolic function.
- Diastolic function assessment is crucial for understanding cardiac implications in treated genetic hemochromatosis.
Purpose of the Study:
- To investigate resting diastolic cardiac function in patients with genetic hemochromatosis undergoing phlebotomy treatment.
- To identify age-related changes in diastolic function within this patient cohort.
Main Methods:
- Echocardiographic assessment of diastolic function was performed in 132 treated genetic hemochromatosis patients and 50 controls.
- Multivariate analyses were conducted to evaluate associations independently of other physiological parameters.
Main Results:
- Patients exhibited higher transmitral early (E) and atrial (A) velocity time integrals, and elevated E/E' ratios compared to controls.
- Independent multivariate analyses confirmed significant associations between hemochromatosis and impaired diastolic function parameters.
- The youngest patient tertile displayed longer isovolumic relaxation time and reduced E' velocities.
Conclusions:
- Findings suggest mildly impaired diastolic function in treated genetic hemochromatosis.
- Delayed relaxation is noted in younger patients, while older patients show signs of elevated filling pressure and pseudonormalization.
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